PEDIATRICS Vol. 86 No. 1 July 1990, pp. 65-70
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Physical Development and Medical History of Children Who Were Treated Antenatally With Corticosteroids to Prevent Respiratory Distress Syndrome: A 10- to 12-Year Follow-up

H. Smolders-de Haas MD1, J. Neuvel MSc1, B. Schmand MSc1, p. E. Treffers MD, PhD1, J. G. Koppe MD, PhD1, and J. Hoeks PhD1

1 From the Departments of Obstetrics and Neonatology, Academic Medical Centre, and the Department of Developmental Psychology, University of Amsterdam, The Netherlands

Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. The children had a general physical examination; parents were interviewed about the medical history of their child with special attention to infectious diseases; growth data were collected; and a developmental neurological examination, an ophthalmological examination, and a lung function test were conducted. In the corticosteroid group significantly more hospital admissions because of infectious diseases during the first years of life were reported. On the other variables no differences between the corticoid and the placebo groups were found.

Key Words: respiratory distress syndrome • corticosteroids • infectious diseases • medical history

Submitted on February 27, 1989
Accepted on July 27, 1989




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