PEDIATRICS Vol. 86 No. 1 July 1990, pp. 58-64
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Psychological Development of Children Who Were Treated Antenatally With Corticosteroids to Prevent Respiratory Distress Syndrome

B. Schmand MSc1, J. Neuvel MSc1, H. Smolders-de Haas MD1, J. Hoeks PhD1, P. E. Treffers MD, PhD1, and J. G. Koppe MD, PhD1

1 From the Departments of Neonatology and Obstetrics, Academic Medical Centre, and the Department of Developmental Psychology, University of Amsterdam, The Netherlands

Potential side effects of antenatal administration of corticosteroids to prevent neonatal respiratory distress syndrome were studied in 10- to 12-year-old children whose mothers had participated in a randomized, double-blind, placebo-controlled trial of betamethasone. Aspects of the children's intellectual and motor development, school achievement, and social-emotional functioning were investigated. There were no differences between the corticoid group and the placebo group on these variables, nor were there more children with learning difficulties and behavioral disturbances in either of the groups.

Key Words: respiratory distress syndrome • corticosteroids • intellectual development • learning disabilities

Submitted on April 5, 1988
Accepted on March 6, 1989




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