PEDIATRICS Vol. 85 No. 6 June 1990, pp. 1103-1107
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ware, J.
Right arrow Articles by McCormick, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ware, J.
Right arrow Articles by McCormick, M. C.

Health and Developmental Outcomes of a Surfactant Controlled Trial: Follow-Up at 2 Years

Janice Ware PhD1, H. William Taeusch MD1, Roger F. SoIl MD1, and Marie C. McCormick MD, ScD1

1 From the Department of Medicine, Harvard Medical School, Boston, Massachusetts, Department of Pediatrics, King/Drew Medical Center, Los Angeles, California, and the Department of Pediatrics, University of Vermont, Burlington

Several randomized clinical trials have shown that surfactant therapy improves the pulmonary status of infants with respiratory distress syndrome and has the potential to reduce morbidity and mortality in these infants. Relatively little is known, however, about the long-term consequences of surfactant treatment. In this report, the results of health and developmental assessment are described at 1 and 2 years of age of 32 survivors of an initial group of 41 infants enrolled in a randomized clinical trial of bovine surfactant therapy. The frequencies of abnormal findings were comparable in the two groups although there was a trend toward a greater frequency of allergic manifestations in the control group (6 of 16 (38%) vs 1 of 15 (7%), P = .08). Similarly, no differences were seen in the mental and motor scores of the Bayley Scales of Infant Development at either 1 or 2 years of age. This study and other recently published reports of follow-up studies of infants treated with surfactant provide encouraging evidence that major long-term side effects do not result from surfactant therapy.

Key Words: surfactant • developmental outcome • respiratory distress syndrome

Submitted on August 31, 1989
Accepted on January 3, 1990




This article has been cited by other articles:


Home page
 NEJMHome page
A. H. Jobe
Pulmonary Surfactant Therapy
N. Engl. J. Med., March 25, 1993; 328(12): 861 - 868.
[Full Text]

Home page
 JWatch GeneralHome page
AN UPDATE ON SURFACTANT THERAPY
Journal Watch (General), June 12, 1990; 1990(612): 5 - 5.
[Full Text]