PEDIATRICS Vol. 85 No. 6 June 1990, pp. 1072-1075
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Dose-Response Relationship of Inhaled Metaproterenol Sulfate in Preschool Children With Mild Asthma

Eliezer Nussbaum MD1, Mario Eyzaguirre MD1, and Stanley P. Galant MD1

1 From the Children's Lung Center, Miller Children's Hospital, Long Beach and the Department of Pediatrics, University of California, Irvine

The dose-response relationship of single doses of nebulized metaproterenol sulfate 5% inhalant solution was evaluated by placebo-controlled, parallel-group study of 30 children, aged 3 to 6 years old, with stable asthma. Total respiratory resistance, the primary variable used to assess response, was measured by the forced oscillation method for a period of 6 hours from the start of inhalation. When comparisons were made between metaproterenol sulfate and saline, only 0.01 and 0.02 mL/kg showed significant bronchodilation (P < .05) in percent change from baseline and area under the curve. However, no significant differences were seen between these doses. Moreover, the effect was sustained for 3 hours with both higher doses. Minimal side effects were observed. Metaproterenol sulfate 5% inhalant solution at a dose of 0.01 mL/kg seems to be optimal to elicit significant and sustained bronchodilatory response in preschool children with mild asthma.

Key Words: metaproterenol súlfate • asthma

Submitted on July 24, 1989
Accepted on August 29, 1989




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