PEDIATRICS Vol. 85 No. 4 April 1990, pp. 589-592
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Transient Organic Aciduria and Methemoglobinemia With Acute Gastroenteritis

MARK A. KAY MD, PHD1, WILLIAM O'BRIEN PHD2, BRADLEY KESSLER MD3, ROBERT MCVIE MD4, SUSONNE URSIN MD4, KENNETH DIETRICH MD4, and EDWARD R. B. MCCABE MD, PHD5

1 Department of Pediatrics, Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas
2 Institute for Molecular Genetics, Baylor College of Medicine, Howard Hughes Medical Institute, Houston, Texas
3 Department of Pediatrics, Baylor College of Medicine
4 Department of Pediatrics, Louisiana State University Medical Center, Shreveport, Louisiana
5 Institute for Molecular Genetics, Department of Pediatrics, Baylor College of Medicine

Acute gastroenteritis remains a common medical problem in the pediatric population and diarrhea may be life threatening in the neonate. Organic aciduria has been observed in children with short bowel, malabsorption, and Hirschsprung's disease,1-6 and methemoglobinemia has been observed in children with acute diarrheal disease.7-15 The two infants described here, however, represent the initial report of concomitant transient organic aciduria and methemoglobinemia in patients with diarrhea. Awareness of the association of these findings will be valuable in directing the clinical evaluation of similar patients.

Submitted on March 23, 1989
Accepted on June 2, 1989