PEDIATRICS Vol. 85 No. 4 April 1990, pp. 455-463
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scheidt, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scheidt, P. C.

Phototherapy for Neonatal Hyperbilirubinemia: Six-Year Follow-up of the National Institute of Child Health and Human Development Clinical Trial

Peter C. Scheidt MD, MPH1, Dolores A. Bryla MPH1, Karin B. Nelson MD1, Deborah G. Hirtz MD1, Howard J. Hoffman MA1, and Principal Investigators

1 From the Biometry and Mathematical Statistics Branch, Prevention Research Program, and the Human Learning and Behavior Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development; and the Neuroepidemiology Branch and the Developmental Neurology Branch, National Institute of Neurological Disorders and Stroke

The National Institute of Child Health and Human Development Randomized, Controlled Trial of Phototherapy for Neonatal Hyperbilirubinemia was conducted to determine whether phototherapy used to control serum bilirubin is safe and is as effective in preventing brain injury as exchange transfusion. The study, conducted at six neonatal care centers, randomly assigned 1339 newborn infants to phototherapy or control groups by the following subgroups: (1) birth weight <2000 g; (2) birth weight 2000 to 2499 g and bilirubin level >171 µmol/L (10 mg/dL); or (3) birth weight ge2500 g and bilirubin level >222 µmol/L (13 mg/dL). Phototherapy was administered for 96 hours, and exchange transfusion was used to control hyperbilirubinemia at the same predetermined levels in both groups. Neurological and developmental examinations were conducted at 1 and 6 years of age, with follow-up rates of 83% and 62%, respectively. The two groups did not differ in mortality or diagnosed medical conditions. The phototherapy and control groups had similar rates of cerebral palsy (5.8% vs 5.9%), other motor abnormalities including clumsiness and hypotonia (11.1% vs 11.4%), and sensorineural hearing loss (1.8% vs 1.9%). The Wechsler Intelligence Scale for Children-Revised scores overall were not significantly different for the two groups (Verbal, 96.8 vs 94.8; Performance, 95.8 vs 95.1 for phototherapy and control groups, respectively). Phototherapy effectively controlled neonatal hyperbilirubinemia without evidence of adverse outcome at 6 years of age and was at least as effective as management with exchange transfusion alone.

Key Words: phototherapy • neonatal hyperbilirubinemia

Submitted on April 28, 1989
Accepted on August 1, 1989




This article has been cited by other articles:


Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
C V Hulzebos, D E van Imhoff, A F Bos, C E Ahlfors, H J Verkade, and P H Dijk
Usefulness of the bilirubin/albumin ratio for predicting bilirubin-induced neurotoxicity in premature infants
Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2008; 93(5): F384 - F388.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
K. A. Jangaard, D. B. Fell, L. Dodds, and A. C. Allen
Outcomes in a Population of Healthy Term and Near-Term Infants With Serum Bilirubin Levels of >=325 {micro}mol/L (>=19 mg/dL) Who Were Born in Nova Scotia, Canada, Between 1994 and 2000
Pediatrics, July 1, 2008; 122(1): 119 - 124.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
E. Matichard, A. Le Henanff, A. Sanders, J. Leguyadec, B. Crickx, and V. Descamps
Effect of Neonatal Phototherapy on Melanocytic Nevus Count in Children
Arch Dermatol, December 1, 2006; 142(12): 1599 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
W.-X. Chen and V. Wong
Visual Evoked Potentials in Neonatal Hyperbilirubinemia
J Child Neurol, January 1, 2006; 21(1): 58 - 62.
[Abstract] [PDF]

Home page
 PediatricsHome page
Subcommittee on Hyperbilirubinemia
Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation
Pediatrics, July 1, 2004; 114(1): 297 - 316.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
J F Watchko and M J Maisels
Jaundice in low birthweight infants: pathobiology and outcome
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2003; 88(6): F455 - 458.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
W. Oh, J. E. Tyson, A. A. Fanaroff, B. R. Vohr, R. Perritt, B. J. Stoll, R. A. Ehrenkranz, W. A. Carlo, S. Shankaran, K. Poole, et al.
Association Between Peak Serum Bilirubin and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants
Pediatrics, October 1, 2003; 112(4): 773 - 779.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
L. R. Atkinson, G. J. Escobar, J. I. Takayama, and T. B. Newman
Phototherapy Use in Jaundiced Newborns in a Large Managed Care Organization: Do Clinicians Adhere to the Guideline?
Pediatrics, May 1, 2003; 111(5): e555 - 561.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
P. A. Dennery, W. D. Rhine, and D. K. Stevenson
Neonatal Jaundice What Now?
Clinical Pediatrics, February 1, 1995; 34(2): 103 - 107.
[PDF]

Home page
 CLIN PEDIATRHome page
J. E. Hodgman and N. Edwards
Racial Differences in Neonatal Jaundice: Hyperbilirubinemia in Hispanic Infants A Survey
Clinical Pediatrics, December 1, 1992; 31(12): 719 - 722.
[PDF]

Home page
 JWatch GeneralHome page
PHOTOTHERAPY IS EFFECTIVE FOR TREATING HYPERBILIRUBINEMIA
Journal Watch (General), April 13, 1990; 1990(413): 7 - 7.
[Full Text]