PEDIATRICS Vol. 85 No. 2 February 1990, pp. 219-221
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Corticosteroids in the Management of Cystitis Secondary to Chronic Granulomatous Disease

REBECCA J. COLLMAN MD1 and JOSEPH D. DICKERMAN MD1

1 Dept of Pediatrics, University of Vermont, College of Medicine, Burlington, Vermont

Chronic granulomatous disease refers to a group of inherited disorders characterized by a deficit in phagocytic-cell oxidative metabolism, resulting in recurrent pyogenic infections due to defective intracellular killing of microorganisms.1 Granulomas form in various organs or tissues, presumably in an attempt to "wall off" the infection, and these can be a major cause of morbidity when vital structures are obstructed or compromised. Cultures of the granulomas are usually negative, although antibiotics have been advocated in the treatment of this complication. Recently, three patients with chronic granulomatous disease-two with gastrointestinal and genitourinary involvement2 and one with pulmonary involvement3—were treated with corticosteroids, which resulted in an amelioration of symptoms.

Submitted on March 10, 1989
Accepted on April 27, 1989




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