PEDIATRICS Vol. 84 No. 3 September 1989, pp. 407-411
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van de Bor, M.
Right arrow Articles by Vielvoye, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van de Bor, M.
Right arrow Articles by Vielvoye, G. J.

Early Detection of Delayed Myelination in Preterm Infants

Margot van de Bor MD, PhD1, Gerard L. Guit MD, PhD1, Anneke M. Schreuder MD1, John Wondergem MD1, and G. Jan Vielvoye MD, PhD1

1 The Departments of Pediatrics and Diagnostic Radiology, University Hospital Leiden, The Netherlands.

Myelination of the central nervous system can be demonstrated with magnetic resonance imaging. The influence of periventricular-intraventricular hemorrhage and periventricular leukomalacia on cerebral myelination was studied using magnetic resonance imaging. The subjects were 33 preterm infants of less than 30 weeks' gestation studied at 44 weeks' postmenstrual age: 11 infants with periventricular-intraventricular hemorrhage, 7 with periventricular leukomalacia, and 15 without periventricular-intraventricular hemorrhage or periventricular leukomalacia. There were no differences in mean gestational age and birth weight between the three groups. However, infants without periventricular-intraventricular hemorrhage or periventricular leukomalacia had significantly less respiratory distress syndrome. At 44 weeks postmenstrual age, infants with periventricular leukomalacia had a significantly delayed myelination pattern (stage M2) in comparison with infants without periventricular-intraventricular hemorrhage or periventricular leukomalacia and infants with periventricular-intraventricular hemorrhage (stages M3 and M4). The latter two groups had myelination stages that were similar to those of healthy term infants at 44 weeks' postmenstrual age. The results demonstrate that periventricular leukomalacia causes delayed myelination of the cerebrum, whereas periventricular-intraventricular hemorrhage does not.

Key Words: myelination • central nervous system • periventricular-intraventricular hemorrhage • periventricular leukomalacia • preterm infant

Submitted on July 29, 1988
Accepted on October 5, 1988




This article has been cited by other articles:


Home page
 J. Immunol.Home page
C. Sherwin and R. Fern
Acute Lipopolysaccharide-Mediated Injury in Neonatal White Matter Glia: Role of TNF-{alpha}, IL-1{beta}, and Calcium
J. Immunol., July 1, 2005; 175(1): 155 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
S J Counsell, M A Rutherford, F M Cowan, and A D Edwards
Magnetic resonance imaging of preterm brain injury
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2003; 88(4): F269 - F274.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Fern and T. Moller
Rapid Ischemic Cell Death in Immature Oligodendrocytes: A Fatal Glutamate Release Feedback Loop
J. Neurosci., January 1, 2000; 20(1): 34 - 42.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. A. Back, X. Gan, Y. Li, P. A. Rosenberg, and J. J. Volpe
Maturation-Dependent Vulnerability of Oligodendrocytes to Oxidative Stress-Induced Death Caused by Glutathione Depletion
J. Neurosci., August 15, 1998; 18(16): 6241 - 6253.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
P. Lamont, T. Sachinwalla, and R. Pamphlett
Magnetic Resonance Imaging of Postmortem Infant Brains
J Child Neurol, January 1, 1994; 9(1): 59 - 62.
[Abstract] [PDF]