PEDIATRICS Vol. 84 No. 2 August 1989, pp. 402
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BURNS, E. R.
Right arrow Articles by RUBINSTEIN, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BURNS, E. R.
Right arrow Articles by RUBINSTEIN, A.

In Reply: Thrombocytopenia and Pediatric Patients With AIDS

EDWARD R. BURNS MD1, MAADHAVA ELLAURIE MD1, and ARYE RUBINSTEIN MD1

1 Dept of Laboratory Medicine, Albert Einstein College of Medicine of Yeshiva University, 1400 Pelham Pkwy S-6N, Bronx, NY 10461

Based upon newly analyzed data, we agree with Dr Weinblatt's well-made point that HIV disease cannot be solely attributed to autoimmune destruction on the basis of elevated levels of platelet-associated IgG. In a recent prospective study of 38 infants and children with HIV infection monitored for as many as 9 years, we demonstrated that, using elevated platelet-associated IgG levels to detect AIDS thrombocytopenia, the sensitivity is 93% but the specificity is 13%. However, when combined with the finding of large circulating platelets as measured by increased mean platelet volume, the specificity is increased to 90%.