PEDIATRICS Vol. 84 No. 2 August 1989, pp. 343-347
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Second-Generation Consequences of Small-for-Dates Birth

Mark A. Klebanoff MD, MPH1, Olav Meirik MD, PhD1, and Heinz W. Berendes MD, MHS1

1 The Prevention Research Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, and the World Health Organization, Geneva, Switzerland

This is the first reported study of birth outcomes of a group of women whose own birth weights and gestational ages had been previously recorded. Births occurring from 1972 to 1983 among 1154 Swedish women, born from 1955 to 1965, were studied. Women who were themselves small for gestational age (SGA) at birth were at increased risk of giving birth to a SGA infant (odds ratio = 2.21, 95% confidence interval = 1.41, 3.48). Women who had been SGA had an even greater increase in risk of giving birth to a preterm infant (odds ratio = 2.96, 95% confidence interval = 1.47, 5.94). Women who were preterm at birth were not at increased risk of giving birth to either preterm (odds ratio = 0.65, 95% confidence interval = 0.15, 2.74) or SGA (odds ratio 1.21, 95% confidence interval = 0.62, 2.38) infants. It is concluded that the long-term effects of intrauterine growth retardation may extend to the next generation; women who had been SGA should be considered at increased risk to give birth to both growth-retarded and preterm infants.

Key Words: small for gestational age infant • low birth weight • preterm infant

Submitted on November 28, 1988
Accepted on January 12, 1989




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