PEDIATRICS Vol. 84 No. 1 July 1989, pp. 90-93
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Relationship of Milk Intake and Vitamin K Supplementation to Vitamin K Status in Newborns

Kunihiko Motohara MD, PhD1, Ikuro Matsukane MD1, Fumio Endo MD, PhD1, Yuji Kiyota MD, PhD1, and Ichiro Matsuda MD, PhD1

1 The Department of Internal Medicine, Kamiamakusa General Hospital, the Department of Pediatrics, Kumamoto University Hospital, and the Department of Obstetrics and Gynecology, Kumamoto Red Cross Hospital, Kumamoto, Japan

Vitamin K status was evaluated by measuring blood acarboxyprothrombin (PIVKA-II) levels on the fifth day of life. The incidence of PIVKA-II-positive infants was higher in breast-fed babies than in those given supplementary (mixed) feeding. The median of total amount of milk intake during the first 3 days was significantly lower in PIVKA-II-positive infants than in PIVKA-II-negative infants among infants given both types of feedings. In addition, there was a significant negative correlation between a positive PIVKA-II proportion and the amount of milk intake in the breast-fed babies. The minimum dose of vitamin K2, necessary to prevent a positive PIVKA-II reading was 15 µg among babies with a normal absorption potential.

Key Words: vitamin K • acarboxyprothrombin • breast-feeding

Submitted on December 2, 1987
Accepted on April 27, 1988