PEDIATRICS Vol. 83 No. 5 May 1989, pp. 657-661
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Blood Pressure Fluctuation and Intraventricular Hemorrhage in the Preterm Infant of Less Than 31 Weeks' Gestation

Vivienne M. Miall-Allen MB, BChir1, Linda S. de Vries MD1, Lilly M. S. Dubowitz MD1, and Andrew G. L. Whitelaw MD1

1 The Royal Postgraduate Medical School, Department of Paediatrics and Neonatal Medicine, Hammersmith Hospital, London, England

A total of 22 infants of less than 31 weeks' gestation who were mechanically ventilated for a minimum of 12 hours for respiratory distress syndrome were studied. The coefficient of variation of direct systolic pressure was measured each minute from six to 36 hours of age and averaged per hour after birth with a microcomputer-based system of data collection. At the start of recording, the ultrasound scan appeared normal in each infant, but intraventricular hemorrhage developed in ten infants less than 36 hours of age. Twelve infants remained free of intraventricular hemorrhages. BP fluctuation was greater for a longer proportion of measured time in infants in whom intraventricular hemorrhage did not develop compared with those in whom it did develop P < .05). These findings do not support a causal relationship between BP fluctuation and intraventricular hemorrhage within the range of coefficient of variation studied.

Key Words: blood pressure fluctuation • intraventricular hemorrhage • pancuronium • preterm infant

Submitted on July 7, 1988
Accepted on October 28, 1988




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