PEDIATRICS Vol. 82 No. 6 December 1988, pp. 835-839
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Unusual Clustering of Allergic Bronchopulmonary Aspergillosis in Children With Cystic Fibrosis

Sabine Maguire MBBCh1, Patricia Moriarty MBBCh1, Edward Tempany FRCPI1, and Muiris FitzGerald MD, FRCP1

1 From Our Lady's Hospital for Sick Children, Crumlin, Dublin

Allergic bronchopulmonary aspergillosis has been recognized in association with cystic fibrosis in children since 1965. Since then, however, there have been a paucity of reports of pediatric cystic fibrosis complicated by allergic bronchopulmonary aspergillosis, and, in most cases, these have been diagnosed retrospectively. A cluster of five acute cases seen during a 4-month period in a single cystic fibrosis center with a systemic illness and deterioration in respiratory status are described. In all five patients, reversible bronchoconstriction and infiltrative changes on x-ray films suggested the diagnosis. This was confirmed by the presence of (1) peripheral blood eosinophilia, (2) elevated total IgE and Aspergillus fumigatus-specific IgE, and (3) circulating serum precipitins against A fumigatus in all cases. All children tested had positive type 1 immediate hypersensitivity to skin tests for A fumigatus, in sputum eosinophilia, and Aspergillus cultured from sputum. Only three of five children were previously noted to be atopic and none had severe advanced suppurative lung disease. All children had previously received bronchodilator therapy and appropriate antibiotics. Following treatment with corticosteroids, acute symptoms and radiologic changes resolved for 1 to 5 months. To date, no children have had recurrence of their allergic bronchopulmonary aspergillosis while receiving alternate-day steroid treatment for 6 months.

Key Words: cystic fibrosis • allergic bronchopulmonary aspergillosis • corticosteroids

Submitted on March 9, 1987
Accepted on December 18, 1987




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