PEDIATRICS Vol. 82 No. 5 November 1988, pp. 810-811
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Varicella Exposure Time

CANDICE E. JOHNSON MD, PHD1

1 Department of Pediatrics, Case Western Reserve University/Cleveland Metropolitan General Hospital, Cleveland, OH 44109

In Reply.—

Dr Brunell's concerns are valid, and we certainly agree that protective efficacy can only be defined by prospective controlled trials, such as that of Weibel et al (N EngI J Med 1984;310:1409). However, we disagree with the concept that data about protection can only be derived from family exposure data. Arbeter et al (Pediatrics 1986;78(suppl):748-756) reviewed all studies of varicella vaccine in healthy children and combined household day-care and playmate exposures as we did.