PEDIATRICS Vol. 82 No. 5 November 1988, pp. 790-792
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Neuroblastoma Associated With Adrenocortical Defects

JULIE BLATT MD1, PETER A. LEE MD, PHD2, and SUZANNE R. TAYLOR MD, PHD3

1 Division of Hematology-Oncology, Children's Hospital of Pittsburgh, Pittsburgh
2 Division of Endocrinology, Children's Hospital of Pittsburgh, Pittsburgh
3 Departments of Pediatrics and Pathology, Children's Hospital of Pittsburgh, Pittsburgh

We reviewed medical charts of all children with a diagnosis of neuroblastoma or ganglioneuroblastoma at the Children's Hospital of Pittsburgh between 1951 and 1987. Two patients were identified among 302 who also had a diagnosis of adrenal hyperplasia. One of these patients has been reported previously.1 Together with other cases identified by literature review, these cases suggest that neuroblastoma and adrenocortical defects may be related pathogenetically.

CASE REPORT

A 3-year-old white boy was seen at the Children's Hospital of Pittsburgh with a history of adrenogenital syndrome and a recent diagnosis of adrenal neuroblastoma. Salt-wasting congenital adrenal hyperplasia was diagnosed when the child was 3 weeks of age (in 1970) and had signs of shock, dehydration, metabolic acidosis, and a serum sodium concentration of 115 mEq/L.