PEDIATRICS Vol. 82 No. 4 October 1988, pp. 678-679
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AIDS-Associated Lymphoma of the Brain in a Child

SHARON B. MURPHY MD1

1 Department of Hematology/Oncology, St Jude Children's Research Hospital and Department of Pediatrics, University of Tennessee, College of Medicine, Memphis

Invited Comment.—

The HIV-infected infant with a primary lymphoma of the brain reported by Professor Cocchi and colleagues from Italy adds another case to the series of pediatric AIDS-associated brain lymphomas already reported by others.1-3 The true frequency of these opportunistic cancers is unknown, but, surely, we are just beginning to see the tip of the iceberg. Neurologic deterioration is common in pediatric AIDS,2 and, unless cases suspicious for brain lymphoma are aggressively investigated by neuroradiologic examinations and brain biopsy, they are unlikely to be diagnosed antemortem.