PEDIATRICS Vol. 82 No. 4 October 1988, pp. 565-570
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jason, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jason, J. M.

Human Immunodeficiency Virus Infection in Hemophilic Children

Janine M. Jason MD1, Jeanette Stehr-Green MD1, Robert C. Holman MS1, Bruce L. Evatt MD1, and The Hemophilia-AIDS Collaborative Study Group

1 From the Division of Host Factors, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, US Department of Health and Human Services, Atlanta

The following groups were compared: (1) children <18 years old who have hemophilia-associated acquired immunodeficiency syndrome (AIDS) with other children with AIDS and with adults who have hemophilia-associated AIDS and (2) asymptomatic HIV-infected hemophilic children with asymptomatic HIV-infected hemophilic adults. Children with hemophilia-associated AIDS were older than other children with AIDS (medians 13 and 1 years, respectively) and less frequently had lymphocytic interstitial pneumonitis (5% v 48%) but had similar incidences of Pneumocystis carinii pneumonia (51% v 53%) and similar case to fatality ratios (59% v 61%). Children with hemophilia-associated AIDS had P carinii pneumonia significantly less often than did adults with hemophilia-associated AIDS, but both had similar case to fatality ratios (adults 72% with P carinii pneumonia, 68% dead). Significantly more hemophilic children than adults with AIDS were nonwhite (30% v 14%) and resided in the tristate area of New York/New Jersey/Pennsylvania (43% v 25%). The immune effects of human immunodeficiency virus (HIV) to date on asymptomatic pediatric and adult hemophiliacs are similar but may be more severe in adults. It is concluded that, although some of the clinical manifestations of AIDS (eg, lymphocytic interstitial pneumonitis) occurring or not occurring in older children infected through blood factor products differ from those of other children with AIDS, disease outcome to date is equally poor. The reasons for the differences between hemophilic children and hemophilic adults with and without AIDS warrant further investigation.

Key Words: human immunodeficiency virus • acquired immunodeficiency syndrome • hemophilia

Submitted on August 14, 1987
Accepted on December 18, 1987




This article has been cited by other articles:


Home page
 Sex. Transm. Infect.Home page
S Das and R F Miller
Lymphocytic interstitial pneumonitis in HIV infected adults
Sex. Transm. Inf., April 1, 2003; 79(2): 88 - 93.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. L. Mankowski, D. L. Carter, J. P. Spelman, M. L. Nealen, K. R. Maughan, L. M. Kirstein, P. J. Didier, R. J. Adams, M. Murphey-Corb, and M. C. Zink
Pathogenesis of Simian Immunodeficiency Virus Pneumonia : An Immunopathological Response to Virus
Am. J. Pathol., October 1, 1998; 153(4): 1123 - 1130.
[Abstract] [Full Text] [PDF]