PEDIATRICS Vol. 82 No. 2 August 1988, pp. 286
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Pink Rings Lymphocyte: A New Cytologic Abnormality Characteristic of Mucopolysaccharidosis Type II (Hunter Disease)

MICHELINE MAIER-REDELSPERGER 1, MARC-HENRI STERN MD1, and PIERRE MAROTEAUX MD2

1 Central Hematology Laboratory, Groupe Hospitalier Necker-Enfants Malades, 75730 Paris Cedex, France
2 INSERM U 12

To the Editor.—

Mucopolysaccharidoses are a group of rare hereditary storage disorders characterized by various lysosomal hydrolase deficiencies. Clinical condition, radiologic and ophthalmologic examinations, urinary mucopolysaccharides dosage, and leukocyte morphology are generally sufficient for diagnosis.1 However, a more precise classification may be difficult. We herein describe a new lymphocyte abnormality observed in 9/9 cases of type II (Hunter disease) in only 3/19 cases of other types of mucopolysaccharidoses.

Capillary blood was collected from 28 children with mucopolysaccharidosis referred to the pediatric department.