PEDIATRICS Vol. 82 No. 2 August 1988, pp. 284
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Barbiturate Anticonvulsants as a Cause of Severe Depression

GABOR BARABAS MD1 and WENDY S. MATTHEWS PHD1

1 223 Monmouth Rd, West Long Branch, NJ 07764

To the Editor.—

In a recent issue, Brent et al1 compared patients treated with phenobarbital with those treated with carbamazepine for seizure disorders. They noted that there was a much higher prevalence of major depressive disorder and suicidal ideation among those taking phenobarbital. They emphasized that the incidence of psychiatric disturbances is higher among epileptic children as compared with controls and that on occasion this may be due to iatrogenic effects of anticonvulsants and not only to factors intrinsic to epilepsy or secondary emotional factors.




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