PEDIATRICS Vol. 82 No. 2 August 1988, pp. 181-192
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Toxoplasmosis: Maternal and Pediatric Findings in 23,000 Pregnancies

John L. Sever MD, PhD1, Jonas H. Ellenberg PhD1, Anita C. Ley MA1, David L. Madden DVM, PhD1, David A. Fuccillo PhD1, Nancy R. Tzan 1, and Dorothy M. Edmonds BS, RN1

1 From the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

An analysis of the antibody titers to toxoplasmosis for 22,845 pregnant women in the Collaborative Perinatal Project was conducted in relation to clinical and laboratory findings in the mothers and children through 7 years of age. More than 900 observations were considered for each mother and child. The major findings were in the children and included a predicted doubling in the frequency of deafness among children born to women with antibody to toxoplasmosis, a predicted 60% increase in microcephaly, and a 30% increase in low IQ (<70) in association with the presence of high maternal antibody titer (256 to 512) to toxoplasma. A serologically defined high-risk group of mothers was identified on the basis of high indirect hemagglutination antibody levels or seroconversions and increased IgM toxoplasma antibody levels (indirect fluorescent antibody ge32, enzyme-linked immunosorbent assay ge0.7). Of the 15 pregnancies in this group, two children had congenital toxoplasmosis and three were stillborn.

Key Words: toxoplasmosis • indirect hemagglutination • indirect fluorescent antibody • enzyme-linked immunosorbent assay

Submitted on August 13, 1987
Accepted on October 21, 1987




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