PEDIATRICS Vol. 82 No. 1 July 1988, pp. 104-106
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lovering, J. S.
Right arrow Articles by McKendry, J. B. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lovering, J. S.
Right arrow Articles by McKendry, J. B. J.

Oxybutynin Efficacy in the Treatment of Primary Enuresis

John S. Lovering MD1, Susan E. Tallett MB1, and James B. J. McKendry MD1

1 From the Enuresis Clinic of the Department of Paediatrics, The Hospital for Sick Children, and the Department of Paediatrics of the University of Toronto, Toronto

The effectiveness of oxybutynin in the treatment of primary enuresis was evaluated in a double-blind study. A total of 30 children (25 boys, five girls), at least 6 years of age, with primary enuresis and no daytime incontinence or history of other urinary tract problems were selected at random from an enuresis clinic population. The study was explained to the families and they were told how to keep records of nocturnal bed-wetting episodes and side effects. The patients were treated with a 10 mg of oxybutynin at suppertime for 28 days. Before or after the treatment period, all children received an identical placebo for 4 weeks. Two-sided paired t tests were used to compare frequency of nocturnal enuresis. Frequency during the drug regimen did not differ significantly from that during the placebo study. There were no differences in findings between boys and girls or between children who had previously taken imipramine and those who had not. The study showed no evidence that oxybutynin is effective in treating primary enuresis.

Key Words: primary nocturnal enuresis • oxybutynin

Submitted on April 3, 1987




This article has been cited by other articles:


Home page
 PediatricsHome page
P. F. Austin, G. Ferguson, Y. Yan, M. J. Campigotto, M. E. Royer, and D. E. Coplen
Combination Therapy With Desmopressin and an Anticholinergic Medication for Nonresponders to Desmopressin for Monosymptomatic Nocturnal Enuresis: A Randomized, Double-Blind, Placebo-Controlled Trial
Pediatrics, November 1, 2008; 122(5): 1027 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
J. H C Evans
Evidence based paediatrics: Evidence based management of nocturnal enuresis
BMJ, November 17, 2001; 323(7322): 1167 - 1169.
[Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
H. Gil Rushton
Older Pharmacologic Therapy for Nocturnal Enuresis
Clinical Pediatrics, July 1, 1993; 32(1_suppl): 10 - 13.
[Abstract] [PDF]