PEDIATRICS Vol. 81 No. 6 June 1988, pp. 893-897
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Haemophilus influenzae Type b Vaccines: Lessons From the Past

ROBERT S. DAUM MD1, EDGAR K. MARCUSE MD2, G. SCOTT GIEBINK MD3, CAROLINE B. HALL MD4, MARTHA L. LEPOW MD5, GEORGE H. MCCRACKEN JR 6, GEORGES PETER MD7, CAROL F. PHILLIPS MD8, HARRY T. WRIGHT JR MD9, and STANLEY A. PLOTKIN MD10

1 Department of Pediatrics, Tulane University School of Medicine, New Orleans
2 Department of Pediatrics, Children's Hospital Medical Center and University of Washington, Seattle
3 Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis
4 Department of Pediatrics, University of Rochester Medical Center, Rochester, NY
5 Department of Pediatrics, Albany Medical College, Albany, NY
6 Department of Pediatrics, University of Texas Health Science Center, Dallas
7 Department of Pediatrics, Rhode Island Hospital and Brown University, Providence
8 Department of Pediatrics, University of Vermont College of Medicine, Burlington
9 Department of Pediatrics, Children's Hospital of Los Angeles and the University of Southern California School of Medicine, Los Angeles
10 Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia

The Committee on Infectious Diseases of the American Academy of Pediatrics attempts to provide "guidelines that complement the physician's clinical judgment and facilitate the making of well reasoned decisions. Unanswered scientific questions, the complexity of medical practice, new information, and inevitable differences of opinion between experts result in inherent limitations"1 in this process.

With regard to the first-generation Haemophilus b polysaccharide vaccines (HBPV or PRP), the Committee issued a statement on Nov 13, 1987 (PedComm: AAP Member Alert), in which its concern regarding the preliminary efficacy estimates derived from "case-control" studies performed by several investigative groups in various areas in the United States was expressed.




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N. V. A. Committee
Lessons Learned From a Review of the Development of Selected Vaccines
Pediatrics, October 1, 1999; 104(4): 942 - 950.
[Abstract] [Full Text]