PEDIATRICS Vol. 81 No. 6 June 1988, pp. 779-784
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Combined Vaccine Against Measles, Mumps, Rubella, and Varicella

Philip A. Brunell MD1, Valerio M. Novelli MD1, Susan V. Lipton MD1, and Betsy Pollock RN1

1 From the Department of Pediatrics, the University of Texas Health Science Center, San Antonio

A combined measles, mumps, rubella, and varicella vaccine produced seroconversions for all four components similar to that found if measles, mumps, and rubella vaccine or live varicella vaccine were given separately. In addition, those exposed to varicella were completely protected or had only a mild rash. Moreover, the reaction rates were not increased if the vaccines were combined. The somewhat lower and delayed serologic response to live varicella vaccine as compared with the combined measles, mumps, rubella, and varicella may have been due to the small amount of varicella vaccine virus used or to its degree of attenuation. Persistence of antibody was observed 1 year postimmunization.

Key Words: combined vaccine • measles • mumps • rubella • varicella

Submitted on June 1, 1987
Accepted on July 10, 1987


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