PEDIATRICS Vol. 81 No. 5 May 1988, pp. 726-729
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Corticosteroids for Exacerbations of Asthma: Current Status of the Controversy

MILES WEINBERGER MD1

1 Department of Pediatrics, Pediatric Allergy and Pulmonary Division, University of Iowa Hospitals and Clinics, Iowa City

In 1956, as the result of a multicenter placebo-controlled evaluation, the British Medical Research Council' reported a higher rate of resolution of asthma among hospitalized adults treated with cortisone than among those treated with placebo. However, subsequent trials of corticosterodis for acute exacerbations of asthma have been associated with inconsistent results. A report2 in 1974 showed no effect on asthmatic symptoms or pulmonary function during the first 24 hours of treatment among 45 hospitalized children randomly assigned to receive placebo or parenterally administered corticosteroids, although a small but statistically significant increase in Pao2 was observed. Studies by Kattan et al3 in 1980 and Elbirt et al4 in 1984 further questioned the value of corticosteroids for acute symptoms of asthma in children.




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P. C. Stillwell
Keeping Ahead of Childhood Asthma
Clinical Pediatrics, February 1, 1993; 32(2): 97 - 99.
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