PEDIATRICS Vol. 81 No. 5 May 1988, pp. 712-714
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Nephrolithiasis Following in Utero Diuretic Exposure: An Unusual Case

ALLEN F. FISCHER MD1, BRUCE R. PARKER MD1, and DAVID K. STEVENSON MD1

1 Departments of Pediatrics and Radiology, Stanford University Medical School, Stanford, California

Reports have appeared in the literature describing the relationship between diuretic therapy and nephrocalcinosis or nephrolithiasis in groups of preterm infants. Most of the affected infants were receiving furosemide for the treatment of bronchopulmonary dysplasia. Here, we report an unusual case of nephrolithiasis related to in utero diuretic exposure.

CASE REPORT

The patient was born prematurely at 33 weeks' gestation. The baby's mother was 33 years old, gravada 1, para 0, and had blood type O. She was a class FR diabetic (retinopathy, nephropathy, systemic hypertension), with a medication regimen that included captopril, 25 mg, twice daily; hydralazine, 25 mg, twice daily; and ethacrynic acid, 50 mg, twice daily.

Submitted on April 30, 1987
Accepted on July 9, 1987