PEDIATRICS Vol. 81 No. 5 May 1988, pp. 697-706
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation

Multicenter Trial of Cryotherapy for Retinopathy of Prematurity: Preliminary Results

Cryotherapy for Retinopathy of Prematurity Cooperative Group1

1 From the Cryotherapy for Retinopathy of Prematurity Cooperative Group and the National Eye Institute, Bethesda, Maryland

We report the preliminary 3-month outcome of a multicenter randomized trial of cryotherapy for treatment of retinopathy of prematurity (ROP). Transscleral cryotherapy to the avascular retina was applied to one randomly selected eye when there was threshold disease (defined as five or more contiguous or eight cumulative 30° sectors [clock hours] of stage 3 ROP in zone 1 or 2 in the presence of "plus" disease). An unfavorable outcome was defined as posterior retinal detachment, retinal fold involving the macula, or retrolental tissue. At this writing, 172 infants had been examined 3 months after randomization. An unfavorable outcome was significantly less frequent in the eyes undergoing cryotherapy (21.8%) compared with the untreated eyes (43%). While the surgery was stressful, no unexpected complications occurred during or following treatment. These data support the efficacy of cryotherapy in reducing by approximately one half the risk of unfavorable retinal outcome from threshold ROP.

Key Words: cryotherapy • retinopathy of prematurity




This article has been cited by other articles:


Home page
 Arch OphthalmolHome page
C. Lofqvist, E. Andersson, J. Sigurdsson, E. Engstrom, A.-L. Hard, A. Niklasson, L. E. H. Smith, and A. Hellstrom
Longitudinal Postnatal Weight and Insulin-like Growth Factor I Measurements in the Prediction of Retinopathy of Prematurity
Arch Ophthalmol, December 1, 2006; 124(12): 1711 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
A. Capone Jr, A. L. Ells, A. R. Fielder, J. T. Flynn, G. A. Gole, W. V. Good, J. M. Holmes, G. Holmstrom, X. Katz, J. A. McNamara, et al.
Standard image of plus disease in retinopathy of prematurity.
Arch Ophthalmol, November 1, 2006; 124(11): 1669 - 1670.
[Full Text] [PDF]

Home page
 Arch OphthalmolHome page
C. Jandeck, U. Kellner, and M. H. Foerster
Late Retinal Detachment in Patients Born Prematurely: Outcome of Primary Pars Plana Vitrectomy
Arch Ophthalmol, January 1, 2004; 122(1): 61 - 64.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
E. A. Palmer
Implications of the Natural Course of Retinopathy of Prematurity
Pediatrics, April 1, 2003; 111(4): 885 - 886.
[Full Text] [PDF]

Home page
 JAMAHome page
D. K. Richardson
A Woman With an Extremely Premature Newborn
JAMA, September 26, 2001; 286(12): 1498 - 1505.
[Full Text] [PDF]

Home page
 Arch OphthalmolHome page
R. D. Higgins, A. L. Mendelsohn, M. J. DeFeo, R. Ucsel, and K. D. Hendricks-Munoz
Antenatal Dexamethasone and Decreased Severity of Retinopathy of Prematurity
Arch Ophthalmol, May 1, 1998; 116(5): 601 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
K. A Kennedy, M. A Ipson, D. G Birch, J. E Tyson, J. L Anderson, S. Nusinowitz, L. West, R. Spencer, and E. E Birch
Light reduction and the electroretinogram of preterm infants
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 1997; 76(3): 168F - 173.
[Abstract] [Full Text]

Home page
 JWatch GeneralHome page
CRYOTHERAPY FOR RETINOPATHY OF PREMATURITY
Journal Watch (General), May 17, 1988; 1988(517): 2 - 2.
[Full Text]