PEDIATRICS Vol. 81 No. 4 April 1988, pp. 498-504
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Delaney, J. K.
Right arrow Articles by Kappas, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Delaney, J. K.
Right arrow Articles by Kappas, A.

Photophysical Properties of Sn-Porphyrins: Potential Clinical Implications

John K. Delaney BS1, David Mauzerall PhD1, George S. Drummond PhD1, and Attallah Kappas MD1

1 From The Rockefeller University Hospital, New York

The photophysical properties of Sn-protoporphyrin and two of its synthetic analogues, Sn-mesoporphyrin and Sn-diiododeuteroporphyrin, were examined. All three compounds are potent competitive inhibitors of heme oxygenase, the rate-limiting enzyme in the catabolism of heme to bilirubin, and can suppress completely or diminish significantly experimentally induced or naturally occurring forms of jaundice in animals or man. The results of these studies show that all three compounds have long-lived triplet states which are quenched by molecular oxygen both in solution and when incorporated in liposomes. However, the addition of quenching groups such as iodine to the porphyrin macrocycle results in a marked (approximately 60%) decrease in the triplet yield and a threefold decrease in the triplet lifetime. The triplet yield was shown to be independent of the excitation wavelength, and as a result, the metalloporphyrins were extremely poor photosensitizers when excited in the spectral region commonly used in phototherapy. In the presence of serum albumin, the triplet state of Sn-protoporphyrin was not quenched by oxygen. These results indicate that Sn-porphyrins can be custom designed with considerably reduced photosensitizing properties for potential clinical use as inhibitors of bilirubin production.

Key Words: photobiology • Sn-porphyrin • neonatal hyperbilirubinemia

Submitted on August 13, 1987
Accepted on November 17, 1987




This article has been cited by other articles:


Home page
 NeoReviewsHome page
R. J. Wong, V. K. Bhutani, H. J. Vreman, and D. K. Stevenson
Pharmacology Review: Tin Mesoporphyrin for the Prevention of Severe Neonatal Hyperbilirubinemia
NeoReviews, February 1, 2007; 8(2): e77 - e84.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. Kappas
A Method for Interdicting the Development of Severe Jaundice in Newborns by Inhibiting the Production of Bilirubin
Pediatrics, January 1, 2004; 113(1): 119 - 123.
[Full Text] [PDF]