PEDIATRICS Vol. 81 No. 3 March 1988, pp. 345-349
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Neurologic Events Following Diphtheria-Tetanus-Pertussis Immunization

Alexander M. Walker MD, DrPH1, Hershel Jick MD1, David R. Perera MD, MPH1, Thomas A. Knauss MD, PhD1, and Robert S. Thompson MD1

1 From the Department of Epidemiology, Harvard School of Public Health, Boston, the Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Waltham, Massachusetts, and the Group Health Cooperative of Puget Sound, Seattle

The frequency of serious neurologic events following the administration of 106,000 doses of diphtheria-tetanus-pertussis vaccine at Group Health Cooperative of Puget Sound was determined using a population-based case-control study with disease ascertainment through pharmacy and hospitalization records. There were no cases of acute unexplained encephalopathies in close temporal relation to vaccination. There was the new onset of one serious seizure disorder in the three days following immunization, with 1.13 expected on the basis of chance alone.

Key Words: diphtheria-tetanus-pertussis vaccine • seizure • infantile spasm • encephalopathy

Submitted on February 25, 1987
Accepted on June 23, 1987




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