PEDIATRICS Vol. 81 No. 2 February 1988, pp. 327
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Chloride-Deficient Formulas

ANNE WILLOUGHBY MD, MPH1

1 Pregnancy and Perinatology Branch, CRMC/National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892

In Reply.—

Dr Barness raises three specific concerns about our report that length of exclusive use of chloride-deficient formula in infancy was associated with adverse developmental outcomes. First, he implies that the other specific health problems in the children might account for this dose-response relationship. This could only occur if the other abnormalities (especially hyperbilirubinemia which was the most common of them) were associated both with prolonged use of the defective formula and with reduced test scores.