PEDIATRICS Vol. 81 No. 2 February 1988, pp. 237-246
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Simultaneous Administration of Measles-Mumps-Rubella Vaccine With Booster Doses of Diphtheria-Tetanus-Pertussis and Poliovirus Vaccines

Adamadia Deforest PhD1, Sarah S. Long MD1, Harold W. Lischner MD1, Joseph A. C. Girone MD1, Janet L. Clark PhD1, Ranganathan Srinivasan PhD1, Tobi G. Maguire BS1, Susan A. Diamond BSN1, Ruth P. Schiller MD1, Edward P. Rothstein MD1, Neil Schlackman MD1, Thomas J. Hipp MD1, Ronald L. Souder MD1, and Roger H. Bernier PhD1

1 From the Department of Pediatrics, Temple University School of Medicine and St Christopher's Hospital for Children, Philadelphia; Pennridge Pediatric Associates, Sellersville, Pennsylvania; and the Centers for Disease Control, Atlanta

The safety and efficacy of simultaneous administration of measles-mumps-rubella (MMR), diphtheria-tetanus-pertussis (DTP), and trivalent oral poliovirus (OPV) vaccines in a test group of 405 children were compared with the safety and efficacy of sequential administration of the same vaccines in a control group of 410 children given MMR followed by booster doses of DTP and OPV 2 months later. The study was double blind and placebo controlled with respect to DTP and OPV. Seroconversion rates to measles, mumps, and rubella exceeded 96% in both groups. Geometric mean titers to measles (P = .05) and rubella (P = .004) were higher in the test group, and titers of antibodies to the other seven antigens were similar in both groups. Clinical reaction data were analyzed in 248 of 405 test children and 249 of 410 control children. The rates of serious vaccine-associated reactions were low and similar in the two groups. Some minor side effects were reported more frequently in the test group, but these differences were judged to be related to study design rather than to differences in the safety of the two vaccine schedules. The results indicate that the safety and serologic efficacy of administering MMR simultaneously with reinforcing doses of DTP and OPV in the second year of life is equivalent to the safety and efficacy observed after administering these antigens separately.

Key Words: immunization • vaccination schedule • measles-mumps-rubella • diphtheria-tetanus-pertussis • oral polio vaccine

Submitted on December 12, 1986
Accepted on February 27, 1987




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