PEDIATRICS Vol. 81 No. 1 January 1988, pp. 66-72
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Syndrome of Erythroderma, Failure to Thrive, and Diarrhea in Infancy: A Manifestation of Immunodeficiency

M. T. Glover MB, MRCP1, D. J. Atherton MB, FRCP1, and R. J. Levinsky MB, FRCP1

1 From the Department of Dermatology, The Hospital for Sick Children, and the Department of Immunology, Institute of Child Health, London

Five infants with a triad of symptoms comprising generalized erythroderma, failure to thrive, and diarrhea are presented. All of these children demonstrated significant immunologic abnormalities. This is a recognizable clinical syndrome that reflects immunodeficiency; however, the responsible immunodeficiencies do not appear to be the same in every case. Early investigation and appropriate therapy may considerably reduce morbidity, and mortality in children with this syndrome.

Key Words: erythroderma • diarrhea • failure to thrive • immunodeficiency • infancy

Revised on October 20, 1986
Accepted on December 19, 1986




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