PEDIATRICS Vol. 81 No. 1 January 1988, pp. 31-35
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jacinto, J. S.
Right arrow Articles by Bosu, S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jacinto, J. S.
Right arrow Articles by Bosu, S. K.

Renal Calcification Incidence in Very Low Birth Weight Infants

Josefina S. Jacinto MD1, Houchang D. Modanlou MD1, Michael Crade MD1, Arthur A. Strauss MD1, and Sogba K. Bosu MD1

1 From the Division of Neonatal-Perinatal Medicine, Miller Children's Hospital, Memorial Medical Center of Long Beach, University of California, Irvine

Serial ultrasound examinations were performed on 31 neonates with birth weights of less than 1,500 g for the detection of renal calcifications. Renal calcifications occurred in 20 (64%) of the infants at a mean age of 39.3 ± 26.7 days of life. Infants with renal calcifications had shorter gestations (28.2 ± 1.8 v 31 ± 1.4 weeks, P < .004) and lighter birth weights (924 ± 195 v 1,338 ± 100 g, P < .004) than those infants without renal calcifications (n = 11). Furosemide administration was more common in the infants with renal calcifications (65% v 9.1%, P < .001). The mean total dose of furosemide administered before renal calcifications were noted was 9.59 ± 7.25 mg/kg. The 20 neonates with renal calcifications had a mean urine calcium level of 12.0 ± 6.8 mg/kg/24 hours, mean urine calcium to creatinine ratio of 1.32 ± 1.03 (range 0.3 to 4.45), and a mean alkaline phosphatase concentration of 961 ± 327 IU. Initial parathyroid hormone levels were not different between the two groups, and subsequent determinations in infants with renal calcifications did not differ significantly from initial values. Renal calcifications are fairly common among very low birth weight infants, particularly in those receiving supplemental calcium and furosemide therapy. Although long-term implications of such findings are not known, close monitoring of renal function by serial determinations of urine calcium and urine calcium to creatinine ratios may identify those infants at risk for renal calcifications.

Key Words: renal calcification • very low birth weight infant

Submitted on February 17, 1987
Accepted on April 16, 1987




This article has been cited by other articles:


Home page
 StrokeHome page
M. J.N.L. Benders, F. Groenendaal, C. S.P.M. Uiterwaal, P. G.J. Nikkels, H. W. Bruinse, R. A.J. Nievelstein, and L. S. de Vries
Maternal and Infant Characteristics Associated With Perinatal Arterial Stroke in the Preterm Infant
Stroke, June 1, 2007; 38(6): 1759 - 1765.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. E. Kist-van Holthe, P. H.T. van Zwieten, E. A. Schell-Feith, H. M. Zonderland, H. C. Holscher, R. Wolterbeek, S. Veen, M. Frolich, and B. J. van der Heijden
Is Nephrocalcinosis in Preterm Neonates Harmful for Long-term Blood Pressure and Renal Function?
Pediatrics, March 1, 2007; 119(3): 468 - 475.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
E Porter, A McKie, T J Beattie, J H McColl, N Aladangady, A Watt, and M P White
Neonatal nephrocalcinosis: long term follow up
Arch. Dis. Child. Fetal Neonatal Ed., September 1, 2006; 91(5): F333 - F336.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
M. Bestic and M. D. Reed
Pharmacology Review: Common Diuretics Used in the Preterm and Term Infant
NeoReviews, August 1, 2005; 6(8): e392 - e398.
[Full Text] [PDF]

Home page
 AAP Grand RoundsHome page
A. L. Friedman
Hypocitraturia Is a Risk Factor for Renal Stones in VLBW Infants
AAP Grand Rounds, September 1, 2003; 10(3): 35 - 35.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
Y.-G. Kim, B. Kim, M.-K. Kim, S.-J. Chung, H.-J. Han, J.-A. Ryu, Y.-H. Lee, K.-B. Lee, J. Y. Lee, W. Huh, et al.
Medullary nephrocalcinosis associated with long-term furosemide abuse in adults
Nephrol. Dial. Transplant., December 1, 2001; 16(12): 2303 - 2309.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
A Narendra, M P White, H A Rolton, Z I Alloub, G Wilkinson, J H McColl, and J Beattie
Nephrocalcinosis in preterm babies
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2001; 85(3): F207 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
R Ojala, M Ala-Houhala, S Ahonen, A Harmoinen, V Turjanmaa, S Ikonen, and O Tammela
Renal follow up of premature infants with and without perinatal indomethacin exposure
Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2001; 84(1): 28F - 33.
[Abstract] [Full Text]

Home page
 PediatricsHome page
T. Campfield, G. Braden, P. Flynn-Valone, and S. Powell
Effect of Diuretics on Urinary Oxalate, Calcium, and Sodium Excretion in Very Low Birth Weight Infants
Pediatrics, June 1, 1997; 99(6): 814 - 818.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
C A Jones, S King, N J Shaw, and B A Judd
Renal calcification in preterm infants: follow up at 4-5 years
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 1997; 76(3): 185F - 189.
[Abstract] [Full Text]