PEDIATRICS Vol. 80 No. 6 December 1987, pp. 933-936
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Immunoglobulin Subclass Antibodies to Varicefla-Zoster Virus

Yoshizo Asano MD1, Yuichi Hiroishi MD1, Naoko Itakura MD1, Shigeyuki Hirose MD1, Yuji Kajita MD1, Takao Nagai MD1, Takehiko Yazaki MD1, and Michiaki Takahashi MD1

1 From the Departments of Pediatrics, Fujita Gakuen Health University School of Medicine and Kariya Sogo Hospital, Toyoake and Kariya, Aichi, and Department of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Commercially available mouse monoclonal antibodies to human IgG subclass (IgG1 to IgG4) were applied to an enzyme-linked immunosorbent assay to measure IgG subclass-specific antibodies to varicellazoster virus in children naturally infected with varicellazoster virus and in varicella vaccine recipients. In children naturally infected with varicella-zoster virus, IgG 1 antibody was detected 2 weeks after onset of the disease in all cases, its activity increased at 1 month after onset, and almost equal antibody value was maintained 10 years after infection. This pattern of antibody response was similar to that of total IgG antibody to varicella-zoster virus after natural infection. On the other hand, low antibody activity was found in IgG2 only at 1 month of the disease. The highest antibody level of IgG3 was shown 2 weeks after onset of the disease; then, it gradually decreased, and no antibody activity was detected 10 years later. IgG4 antibody was first detected 1 month after onset and an almost equal level of antibody was shown 10 years after the disease. After inoculation of children with a live varicella vaccine, in contrast, IgG subclass antibody responses to vaccine recipients were almost equal to those after natural infection.

Key Words: varicella-zoster virus • vaccine • immunity • IgG subclass antibody

Submitted on March 16, 1987
Accepted on May 21, 1987




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