PEDIATRICS Vol. 80 No. 6 December 1987, pp. 927-932
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Lipid Composition of Milk From Mothers With Cystic Fibrosis

Joel Bitman PhD1, Margit Hamosh PhD1, D. L. Wood MS1, L. M. Freed PhD1, and P. Hamosh MD1

1 From the Milk Secretion and Mastitis Laboratory, US Department of Agriculture, Beltsville, Maryland and Departments of Pediatrics and Physiology and Biophysics, Georgetown University Medical Center, Washington, DC

Milk lipids from six mothers with cystic fibrosis were compared with milk lipids from six mothers without cystic fibrosis. Mean neutral lipids (in g/dL) were colostrum, 2.4; transitional, 2.9; mature milk, 2.9, suggesting that milk fat content was sufficient to support energy needs of the infant. Lipid class composition was normal, 98% being present as triglyceride. Cholesterol and cholesteryl ester concentrations were similar in the milk of both groups of lactating women. Phospholipid class distribution of cystic fibrosis milk was different from that in control milk. Approximately 85% of the lipids were present in six major fatty acids from 12:0 to 18:2 in both groups, indicating that the profile of most of the lipid was similar. The linoleic acid content of cystic fibrosis milk was decreased significantly to 75% of normal values. Other polyunsaturated fatty acids were elevated in cystic fibrosis milk. Concentrations of 16:2, 18:3, and several longer chain polyunsaturated fatty acids were twice that in the milk of the control women, suggesting increased Dgr-desaturation. Elevated proportions of several other polyunsaturated fatty acid metabolite suggested increased chain elongation to C20 and C22 polyunsaturated fatty acids. These differences in fatty acid patterns in cystic fibrosis milk were similar to differences found in blood lipid patterns of children with cystic fibrosis. These results suggest abnormal polyunsaturated fatty acid nutrition or metabolism in cystic fibrosis.

Key Words: cystic fibrosis • human milk • lipids • phospholipids • polyunsaturated fatty acids

Submitted on February 23, 1987
Accepted on May 21, 1987




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M. Gilljam, M. Antoniou, J. Shin, A. Dupuis, M. Corey, and D. E. Tullis
Pregnancy in Cystic Fibrosis : Fetal and Maternal Outcome
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[Abstract] [Full Text] [PDF]