PEDIATRICS Vol. 80 No. 6 December 1987, pp. 876-879
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Myeloperoxidase Deficiency With Extensive Candidal Osteomyelitis of the Base of the Skull

Michel L. Weber MD1, Anthony Abela MD1, Louis de Repentigny MD1, Laurent Garel MD1, and Normand Lapointe MD1

1 From the Departments of Pediatrics, Microbiology and Immunology, Radiology, and Surgery, University of Montreal and Ste-Justine Hospital, Montreal

A 6-year-old girl had a 7-month history of headaches and painful torticollis. A CT scan of the mastoids showed extensive bone destruction of the base of the skull and C-1. Biopsies of the retropharyngeal area and of the anterior aspect of C-1 were performed: histopathologic findings were suggestive of mycotic infection and cultures were positive for Candida albicans. The child was treated successfully with amphotericin B. The immunologic evaluation demonstrated the absence o myeloperoxidase in the neutrophils.

Key Words: Candida albicans osteomyelitis • myeloperoxidase deficiency • skull osteomyelitis

Submitted on December 24, 1986
Accepted on February 19, 1987




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