PEDIATRICS Vol. 80 No. 6 December 1987, pp. 873-875
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Ceftriaxone Effect on Bilirubin-Albumin Binding

Stacey Fink PhD, MD1, Warren Karp PhD, DMD1, and Alex Robertson MD1

1 From the Section of Neonatology, Department of Pediatrics, Medical College of Georgia, Augusta

The effect of ceftriaxone on bilirubin-albumin binding was measured in vitro using the peroxidase method with human serum albumin and a dialysis rate method with adult and newborn serum. Ceftriaxone competes with bilirubin for binding to human serum albumin; the displacement constant is 1.5 x 104 L/mol. Therapeutic levels of ceftriaxone decrease the reserve albumin concentration in newborn serum by 39%. These results indicate that ceftriaxone may increase the risk of bilirubin encephalopathy in jaundiced premature infants.

Key Words: bilirubin-albumin binding • ceftriaxone

Submitted on October 22, 1986
Accepted on February 23, 1987




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