PEDIATRICS Vol. 80 No. 6 December 1987, pp. 828-835
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Coronary Artery Involvement in Kawasaki Syndrome in Manhattan, New York: Risk Factors and Role of Aspirin

Fukiko Ichida MD1, Nunzia S. Fatica MD1, Mary Allen Engle MD1, John E. O'Loughlin MD1, Arthur A. Klein MD1, Michael S. Snyder MD1, Kathryn H. Ehlers MD1, and Aaron R. Levin MD1

1 From The Division of Pediatric Cardiology, The New York Hospital-Cornell Medical Center, New York

Since January 1980, 110 children having 113 attacks of Kawasaki syndrome were studied. Age at onset was 7 weeks to 12 years (mean 36/12 years, median 29/12 years); 77% were younger than 5 years of age; the male to female ratio was 1.8; racial distribution was 52% white, 19% black, 14% Hispanic, and 16% Asian. Protocol of management consisted of high-dose aspirin (100 mg/kg/d) until afebrile, and then 81 mg every day until free of coronary aneurysm. Two-dimensional echocardiograms were done weekly during the acute stage, at 2 and 6 months after onset, and yearly if a coronary abnormality was detected. At 1 month, 51 coronary arterial abnormalities were present in 25 patients. Risk factors for a coronary abnormality were duration of fever greater than or equal to 2 weeks, level of platelet count, marked elevation of ESR, and age younger than 5 years. No statistically significant difference in incidence of aneurysms was detected between patients on high-dose aspirin and those on medium- or low-dose aspirin.

Key Words: aspirin • Kawasaki syndrome • coronary artery

Submitted on October 13, 1986
Accepted on February 10, 1987




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