PEDIATRICS Vol. 80 No. 5 November 1987, pp. 789-796
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Serum Lipids and Lipoproteins

David S. Freedman PhD1, Sathanur R. Srinivasan PhD1, James L. Cresanta MD1, Larry S. Webber PhD1, and Gerald S. Berenson MD1

1 From the Departments of Medicine, Public Health and Preventive Medicine, Biochemistry, and Biometry and Genetics, Louisiana State University Medical Center, New Orleans

Serum lipids and lipoprotein cholesterol fractions were examined in a newborn cohort that was followed from birth to 7 years of age. Although white and female infants had higher cord blood levels of high-density lipoprotein cholesterol (HDL-C) than did black and male infants, respectively, these differences did not persist throughout early childhood. Mean levels of all serum lipids and lipoproteins increased greatly in the first 6 months of life, and by 2 years of age, levels approached those seen in adolescents. Infants consuming cow's milk had higher 6-month levels of serum total cholesterol and low-density lipoprotein cholesterol than did formula-fed infants. However, milk source in infancy did not significantly influence total cholesterol or low-density lipoprotein cholesterol levels at age 7 years. Serum lipid and lipoprotein levels at age 7 years were associated with previously measured levels as early as 6 months of age, and infants with unfavorable levels were likely to have similar adverse levels at 7 years of age. In addition, increases in obesity between 6 months and 7 years of age were positively associated with increases in levels of serum triglycerides. These results suggest that certain persons at increased risk for cardiovascular disease can be identified in infancy.

Key Words: cardiovascular risk factor • lipoprotein cholesterol • nutrition




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