PEDIATRICS Vol. 80 No. 5 November 1987, pp. 762
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Tocopherol Efficacy and Retinopathy of Prematurity

JAMES B SCHICK MD1, ARNE L. BECK PHD1, and HEMA N. DESILVA MD1

1 Department of Pediatrics, Saint Francis Hospital and Medical Center, Hartford, CT

To the Editor.—

Phelps et al1 are to be congratulated for a massive undertaking to perform a randomized controlled trial of tocopherol for the prevention of retinopathy of prematurity.

We would like to present data which raise a possible uncontrolled aspect of this and other studies of retinopathy of prematurity. We have recently completed a cohort study of all infants weighing 1,000 to 1,500 g during a 2frac12-year period to evaluate the possible role of high (T-6 to T-11) v low (L-3 to L-5) umbilical artery catheter placement as a cause of subependymal/intraventricular hemorrhage.