PEDIATRICS Vol. 80 No. 5 November 1987, pp. 738-740
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Granulocyte Transfusions in Neonates With Presumed Sepsis

MITCHELL S. CAIRO MD1

1 Children's Hospital of Orange County, Orange, CA

Neonatal sepsis is a life-threatening disorder occuring in one to ten patients per 1,000 live births and accounts for almost 10% to 20% of all mortality during the first 28 days of life.1 The outcome of neonatal sepsis is dependent on numerous factors including maternal antenatal complications, maturity and physiologic status of the neonate, and invasive supportive care, such as vascular catheters. Early diagnosis, initiation of appropriate antibiotic therapy, and management of metabolic and respiratory problems can greatly affect the outcome of neonatal sepsis.

Numerous humoral deficiencies in the term and premature neonate predispose to bacterial infection. These include decreased maternally derived specific antibodies,2 decreased levels of circulating fibronectin.4




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