PEDIATRICS Vol. 80 No. 4 October 1987, pp. 600
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Inborn Errors of Metabolism

BARBARA K. BURTON MD1

1 Department of Pediatrics, Section on Medical Genetics, The Bowman Gray School of Medicine, Wake Forest University, 300 S Hawthorne Rd, Winston-Salem, NC 27103

In Reply.—

I thank Drs Wiswell and Weisse for their interesting observations regarding the occurrence of intracranial hemorrhage in term infants with inborn errors of metabolism. There is no question that intracranial hemorrhage is a potentially devastating, although presumably uncommon, complication of these disorders. In my personal experience, neonates with inborn errors of metabolism who have experienced intracranial hemorrhages have all had obvious predisposing factors, such as severe metabolic acidosis, which would provide a clue to the underlying diagnosis.