PEDIATRICS Vol. 80 No. 4 October 1987, pp. 571-574
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Orthotopic Liver Transplantation in Patients With Cystic Fibrosis

Kenneth L. Cox MD1, Richard E. Ward MD1, Terry L. Furgiuele MD1, Robert A. Cannon MD1, Kathleen D. Sanders MD1, and Geoffrey Kurland MD1

1 From the Departments of Pediatrics and Surgery, University of California at Davis

An 11-year-old boy who had cystic fibrosis underwent an orthotopic liver transplantation. His immediate postoperative course was not unusually complicated when compared with other liver transplant recipients. Transplantation did not correct abnormalities in the sweat test or the respiratory disease. Cholestasis due to obstruction of the recipient duct with tenacious bile was cleared by instilling N-acetylcysteine into the duct. On the 48th day after the transplantation, he died of an intraventricular and intracerebral hemorrhage caused by an Aspergillus brain abscess. We conclude that certain patients with cystic fibrosis may be appropriate candidates for liver transplantation, but their pre- and postoperative management may need to differ from other liver transplant recipients.

Key Words: cystic fibrosis • liver • transplantation • aspergillus • brain abscess

Submitted on July 3, 1985
Accepted on November 18, 1986




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R. Wyllie
Gastrointestinal Manifestations of Cystic Fibrosis
Clinical Pediatrics, November 1, 1999; 38(12): 735 - 738.
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