PEDIATRICS Vol. 80 No. 3 September 1987, pp. 434-438
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Gastroduodenal Motility in Neonates: Response to Human Milk Compared With Cow's Milk Formula

T. Tomomasa MD1, P. E. Hyman MD1, K. Itoh MD1, J. Y. Hsu MD1, T. Koizumi MD1, Z. Itoh MD1, and T. Kuroume MD1

1 From the Departments of Pediatrics and Medical Technology, Gunma University School of Medicine, and Gunma Children's Medical Center, Japan, and Harbor-University of California, Los Angeles, Medical Center, Torrance

It is known that breast milk empties more quickly from the stomach than does infant formula. We studied the difference in gastroduodenal motility between neonates fed with human milk and those fed with infant formula. Twenty-four five-to 36-day-old neonates were fed with mother's breast milk or with a cow's milk-based formula. Postprandlial gastroduodenal contractions were recorded manometrically for three hours. Repetitive, high-amplitude nonmigrating contractions were the dominant wave form during the postprandial period. The number of episodes, duration, amplitude, and frequency of nonmigrating contractions were not different following the different feedings. The migrating myoelectric complex, which signals a return to the interdigestive (fasting) state, appeared in 75% of breast milk-fed infants but only 17% of formula-fed infants (P < .05) within the three-hour recording period. Because contractions were similar following the two meals, but a fasting state recurred more rapidly in breast-fed infants, we conclude that factors other than phasic, nonpropagated antroduodenal contractions were responsible for the differences in gastric emptying between breast milk and formula.

Key Words: human milk • infant formula • migrating myoelectric complex • gastroduodenal motility • neonate • cow's milk

Submitted on July 8, 1986
Accepted on October 24, 1986




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