PEDIATRICS Vol. 80 No. 3 September 1987, pp. 355-358
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Familial Occurrence of Sudden Infant Death Syndrome and Apnea of Infancy

Joseph Oren MD1, Dorothy H. Kelly MD1, and Daniel C. Shannon MD1

1 From the Pediatric Pulmonary Unit, Massachusetts General Hospital, Boston

We sought to determine the outcome of infants born to families with multiple victims of sudden infant death syndrome (SIDS) and/or apnea of infancy. Seventy-three infants, born to families who had two or more previous siblings who had either died of SIDS or who were monitored at home for apnea of infancy or for abnormal results on polysomnogram and/or pneumogram recording, were prospectively monitored. The infants underwent polysomnogram and pneumogram recording and were subsequently monitored at home with a cardiorespiratory monitor. All episodes of apnea were immediately reviewed. Thirteen infants (18%) had subsequent severe episodes of apnea and five other infants (7%) died during a subsequent episode. All deaths occurred in families who had two or more SIDS victims. The outcome for the 17 infants who were half siblings was similar to the outcome for full siblings. Clinical data of the infants and results of evaluation were not predictive of outcome.

Key Words: sudden infant death syndrome • apnea • sibling

Submitted on June 5, 1986
Accepted on October 31, 1986




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