PEDIATRICS Vol. 80 No. 1 July 1987, pp. 126-127
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School Performance and Theophylline

GARY S. RACHELEFSKY , JULIE WO , JUDIH ADELSON , M. RAY MICKEY , SHELDON L. SPECTOR , ROGER M. KATZ , SHELDON C. SIEGEL , and ALBERT S. ROHR

In Reply.—

Dr Twarog and colleagues raise a number of questions about our report of the adverse effects of theophylline. We appreciate their concerns and we hope the following satisfies them.

The study was double blinded and randomized; the investigators, the children, the teachers, and the parents had no way of knowing which child was receiving theophylline or placebo, and there was no prior experience with theophylline titration. A "designated'tant' physician monitored the theophylline levels.