PEDIATRICS Vol. 80 No. 1 July 1987, pp. 123-124
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School Performance and Theophylline

GARY S. RACHELEFSKY MD, JULIE WO RN, JUDITH ADELSON MA, M. RAY MICKEY PHD, SHELDON L. SPECTOR MD, ROGER M. KATZ MD, SHELDON C. SIEGEL MD, and ALBERT S. ROHR MD

In Reply.—

Mr Schriver's first concern is the appropriate interpretation of results from placebo-controlled, double-blind clinical trials. Our understanding is that the function of the placebo-treated group is to provide a control against which to judge the effect of the treatment. It is not particularly unusual to observe an "effect" in the placebo "arm" of such a controlled study, and we would consider it inappropriate to emphasize the effect in either arm considered by itself other than in reference to the planning and interpretation of such trials.