PEDIATRICS Vol. 8 No. 5 November 1951, pp. 603-615
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EFFECT OF ADRENOCORTICOTROPHIC HORMONE ON RHEUMATIC FEVER

ALBERT DORFMAN M.D., PH.D.1, KATHERINE SMULL M.D.2, DELBERT M. BERGENSTAL M.D., PH.D.3, ROBERT HOWARD M.D.1, RICHARD MULLER M.D.1, DUNLAP OLESON M.D.1, and EDWARD SENZ M.D.1

1 The Department of Pediatrics, The University of Chicago, and La Rabida Jackson Park Sanitarium, Chicago.
2 Grace M. Clausen Johnson Fellow., The Department of Pediatrics, The University of Chicago, and La Rabida Jackson Park Sanitarium, Chicago.
3 Fellow in Medicine., The Department of Pediatrics, The University of Chicago, and La Rabida Jackson Park Sanitarium, Chicago.

ACTH therapy represses the manifestations of active rheumatic fever including those of carditis. There is as yet no conclusive evidence as to whether ACTH therapy affects the natural course of rheumatic fever. A relatively large percentage of patients in this study showed evidence of reactivation of disease on withdrawal of drug.

As used in these studies ACTH therapy did not uniformly prevent death due to acute rheumatic pancarditis. There is no evidence to indicate whether treatment of active rheumatic fever with ACTH changes the incidence of late valvular deformities.

Submitted on February 9, 1951




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