PEDIATRICS Vol. 8 No. 4 October 1951, pp. 527-533
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PRODUCTION OF CONGENITAL DEFECTS IN THE OFFSPRING OF PREGNANT MICE TREATED WITH CORTISONE

Progress Report

F. CLARKE FRASER PH.D., M.D.1 and T. D. FAINSTAT B.SC.1

1 The Department of Genetics, McGill University, and the Children's Memorial Hospital of Montreal.

It has been shown that cortisone, injected into pregnant female mice, will produce cleft palate and other congenital malformations in the resulting young. The incidence of cleft palate varies according to the genetic constitution of the treated mice, the dosage of cortisone used and the gestational stage at which treatment is begun.

Submitted on April 26, 1951




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