PEDIATRICS Vol. 8 No. 2 August 1951, pp. 177-191
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SILVERMAN, W. A.
Right arrow Articles by BLODI, F. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SILVERMAN, W. A.
Right arrow Articles by BLODI, F. C.

INHIBITION OF GROWTH AND OTHER EFFECTS OF ACTH IN PREMATURE INFANTS

WILLIAM A. SILVERMAN M.D.1, RICHARD L. DAY M.D.1, and FREDERICK C. BLODI M.D.1

1 The Department of Pediatrics, College of Physicians and Surgeons, Columbia University and the Babies Hospital, and the Institute of Ophthalmology of the Presbyterian Hospital, New York City.

Premature infants who received more than ACTH 5 mg./kg./day became hyperirritable and ravenous. Many became pallid immediately after injection of the hormone. During the course of treatment infections which appeared could be controlled with antibacterial therapy.

Untreated premature infants excreted increasing amounts of chemically assayed urinary "corticosteroids" with increased body weight. Under the influence of doses of ACTH in excess of 5 mg./kg./day the urinary excretion of "corticosteroids" increased significantly.

Retardation of growth occurred during the administration of more than 5 mg. ACTH/ kg./day. "Rebound" increase in growth took place upon cessation of hormonal administration.

Submitted on March 19, 1951