PEDIATRICS Vol. 79 No. 6 June 1987, pp. 928-934
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Convulsions Caused by Endrin Poisoning in Pakistan

Diane L. Rowley MD1, Mohammed A. Rab MBBS, MPH1, Witjaksono Hardjotanojo MD1, John Liddle PhD1, Virlyn W. Burse 1, Mohammed Saleem 1, David Sokal MD1, Henry Falk MD, MPH1, and Susan L. Head 1

1 From the Center for Environmental Health, Centers for Disease Control Public Health Service, US Department of Health and Human Resources, Atlanta, and the Pakistan National Institute of Health and Office of the World Health Organization, Islamabad, Pakistan

From July through September 1984, acute convulsions caused by endrin poisoning occurred in the subdistrict of Talagang, Attock District, Punjab province, Pakistan. Eighteen of the 21 affected villages were surveyed; 70% of the cases for which ages were known (106 of 152) were in children 1 to 9 years of age; 9.8% of all affected persons (19 of 194) died. The outbreak occurred in villages on the main roads of the subdistrict and peaked in early September. Endrin was detected in the blood of 12 of 18 patients with a history of convulsions but was not found in the blood of four hospitalized control patients. One composite sugar sample taken from the homes of three persons had an endrin level of 0.04 ppm. Because of the high toxicity, repeated association with large-scale outbreaks of neurologic illness, and the difficulties of monitoring distribution, endrin should not be used for agricultural purposes.

Key Words: endrin • convulsion • pesticide poisoning

Submitted on June 23, 1986
Accepted on August 26, 1986




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